Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions. - Mechanism of Action & Protocol.
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Chemical Name : Mitotane-d4
PDF) Determination of Mitotane (DDD) and Principal Metabolite by a Simple HPLC-UV Method and Its Validation in Human Plasma Samples
Exposure to anticancer drugs modulates the expression of ACSL4 and ABCG2 proteins in adrenocortical carcinoma cells - ScienceDirect
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Frontiers Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study
The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells
Exposure to anticancer drugs modulates the expression of ACSL4 and ABCG2 proteins in adrenocortical carcinoma cells - ScienceDirect
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The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
Mitotane Tablets Cost-Price In India
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Mitotane, C14H10Cl4
Structural Requirements for Mitotane Activity: Development of Analogs for Treatment of Adrenal Cancer
