Crowther and Dolton et al. identified an unconventional human T cell clone capable of killing many different types of cancer in vitro in an HLA-independent fashion while sparing healthy cells. Using genome-wide CRISPR-Cas9 screening, the researchers showed that the T cell clone recognized the ubiquitously expressed, mostly monomorphic, MHC-I-related protein MR1 on the surface of cancer cells when MR1 was loaded with a yet unidentified cancer-specific or cancer-associated ligand. Adoptive transfer of this T cell clone into immunodeficient NSG mice with leukemia reduced tumor burden and increased survival.
Skeleton Key” T-Cell Receptor Works across Multiple Cancer Types
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1
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Michael G King Jr (@MichaelGKingJr) / X
Pan-cancer T cell atlas links a cellular stress response state to
Can we predict T cell specificity with digital biology and machine
Frontiers Platelet detection as a new liquid biopsy tool for
Frontiers γδ T cells as a potential therapeutic agent for
Genetic and pharmaceutical targeting of HIF1α allows combo
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Frontiers Gamma/delta T cells as cellular vehicles for anti
Michael G King Jr (@MichaelGKingJr) / X
Gamma/delta T cells as cellular vehicles for anti-tumor - Frontiers
Frontiers Progress Toward Identifying Exact Proxies for
