Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap (SJS/TEN), collectively referred to SJS/TEN, form a spectrum of severe life-threatening adverse drug reactions whose pathomechanism is not fully understood. The article "Photodistributed Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Proposal for a New Diagnostic Classification" by McKinley et. al., discusses a distinct distribution of epidermal necrosis in SJS/TEN, attributable to preceding exposure to ultraviolet radiation (UVR), and relative sparing of photo-protected areas. After reviewing numerous cases within the Immune-mediated Adverse drug Reactions in African HIV endemic setting Register and Biorepository (IMARI-SA) at the University of Cape Town with a similar clinical pattern as those published by McKinley et. al., we propose that the relative sparing of some areas giving an impression of photo-distribution is due to localised increase in skin pressure that reduces the blood supply in that area below a critical threshold. A dip in blood supply below this critical threshold quantitively limited T lymphocytes and cytokines that drive SJS/TEN to reach and damage the skin.
Distinguishing Benign Rashes From Severe Skin Reactions From Anti
Guidelines for the management of Stevens–Johnson syndrome/toxic
A review of causes of Stevens–Johnson syndrome and toxic epidermal
Frontiers Stevens-Johnson syndrome and toxic epidermal
PDF) Severe Delayed Cutaneous and Systemic Reactions to Drugs: A
Predictive biomarkers for the progression of ocular complications
Cancers, Free Full-Text
Poster Presentations - 2018 - Australasian Journal of Dermatology
How Drug Photodegradation Studies Led to the Promise of New
Bibliometric analysis of literature on toxic epidermal necrolysis and Stevens-Johnson syndrome: 1940 – 2015, Orphanet Journal of Rare Diseases
Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis
Frontiers Stevens-Johnson syndrome and toxic epidermal
Calaméo - Atlas Of Graft Versus Host Disease Approaches To
Lightning Learning: Stevens-Johnson syndrome (SJS) — EM3
How Drug Photodegradation Studies Led to the Promise of New