Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 • Malignant lymphoma that is typically of B-cell origin • Etiology: Immunosuppression (e.g., HIV), EBV infection, Autoimmune diseases • Clinical features: - Adenopathy (painless)-localized above the diaphragm, - Contiguous spread - Lymph nodes in upper portion of the body (the neck, underarms, or chest). - B symptoms - Pel-Ebstein fever - Alcohol-induced pain: Pain in involved lymph nodes - Pruritus: (focal or generalized) • Usually no hepatosplenomegaly (Rare but might occur if the spleen or liver are involved) • No leukemic phase • Reed Sternberg cell • Prognosis: Good • ABVD , BEACOPP Non-Hodgkin's Lymphoma: • Epidemiology: Increases with age (peak > 50 years) • Etiology: - Infections (HIV, EN, HTLV-1, HCV, H. Pylori) - Autoimmune diseases (e.g., Hashimoto thyroiditis, rheumatic disease) - Chromosomal translocation • Types: Classification based on: - Cell type (B cell, T cells, natural killer (NK) cells) - Location (nodal or extranodal) - Tumor grade • Adenopathy + Extranodal (Multiple lymph node groups) - Lymph nodes throughout the body, but can also arise in normal organs - Noncontiguous spread • Clinical features: - Nodal disease: B symptoms, lymphadenopathy, mass, Hepatosplenomegaly, cytopenias(bleeding) - Extranodal disease: GI, neuro, cutaneous involvement #Hodgkins #Lymphoma #NonHodgkins #comparison #oncology #diagnosis
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